Curcumin is an anti-inflammatory compound from the spice turmeric. it has been used for centuries in Chinese and Ayurvedic medicine to relieve swelling and pains in the joints. Curcumin has shown to specifically protect cartilage cells from inflammatory factors. It blocks the enzymes responsible for promoting inflammation. Studies have demonstrated that curcumin may be as effective as ibuprofen on pain with walking and stair climbing. It is safe and well tolerated by most, though patients on blood thinning medications should be cautious. Black pepper was used as a folk medicine to treat a variety of conditions and diseases, including muscle pains, chills, fevers, migraines, and digestive problems. It was also used to enhance blood circulation and stimulate appetite. Piperine is the active compound in black pepper, and It gives black pepper its spicy taste and beneficial effects. Piperine is well known for its effect of improving the bioavailability of other drugs or nutrients. In several researches, consuming piperine with other supplements has been shown that it helps our bodies make use of those more effectively. Piperine increases the bioavailability of curcumin, a compound found in turmeric, in rats by 154%, and in humans by 2,000%.